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Buller ", "Description": "Estimates statistically significant marker combination\nvalues within which one immunologically distinctive group\n(i.e., disease case) is more associated than another group\n(i.e., healthy control), successively, using various\ncombinations (i.e., \"gates\") of markers to examine features of\ncells that may be different between groups. For a two-group\ncomparison, the 'gateR' package uses the spatial relative risk\nfunction estimated using the 'sparr' package. Details about the\n'sparr' package methods can be found in the tutorial: Davies et\nal. (2018) . Details about kernel density\nestimation can be found in J. F. Bithell (1990)\n. More information about relative\nrisk functions using kernel density estimation can be found in\nJ. F. 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